In more severe cases of diabetic retinopathy, leaky capillaries may become permanently damaged and may not work at all. This capillary damage results in lack of blood flow to sections of the retina (ischemia). Ischemia results in the production of chemical messengers in the retina that lead to development of abnormal new blood vessels (retinal neovascularization) that can grow out of the retina and into the vitreous (the jelly like substance that fills the eye). This is called proliferative diabetic retinopathy (PDR). Unfortunately, these new blood vessels are not helpful. They are fragile and can bleed causing the back of the eye to fill with blood causing string-like floaters, then hazy, and loss of vision. These abnormal blood vessels also grow with a scar tissue that can begin to pull on the retina and lead to a retinal detachment. At this stage, surgery is often required and if not caught in time, this can lead to permanent loss of vision.
Much of the changes and damage that occur with diabetic retinopathy happen before any symptoms develop so it’s important to have routine eye exams if you have diabetes. Plus, the disease is much easier to treat if caught early. PDR can be treated with laser in the office or with the injection of anti-VEGF (vascular endothelial growth factor) medications.
The most important way to prevent vision loss in diabetes is to keep blood sugars and blood pressures under good control. Keeping the hemoglobin A1C (long term measure of sugar control) under 7.0 is extremely important. Tight blood sugar control reduces the risk of developing diabetic retinopathy. Even if retinopathy develops, patients with tight control tend to have mild and non-sight threatening retinopathy. Annual check-ups by your eye doctor or retina specialist after the diagnosis of diabetes and more frequent follow-up evaluation once diabetic retinopathy develops is important. Women who have diabetes and become pregnant may need very close monitoring during pregnancy.